Excess Omega-6 in diet may promote obesity.
A Norwegian PhD study shows that a dietary approach addressing an underlying cause of endocannabinoid hyperactivity may be a safe and viable alternative for preventing and decreasing obesity.
Dietary intakes of linoleic acid (LA, 18:2 omega-6) has increased dramatically during the 20th century. LA is the precursor of arachidonic acid (AA, 20:4 Omega-6), the backbone of the endocannabinoids 2-AG and AEA. A sustained hyperactivity of the endocannabinoid system is believe to play a causal role in the development of obesity and associated metabolic disorders.
The Norwegian PhD student Anita Røyneberg Alvheim showed that 8 en% intake of LA induces hyperactivity of the endocannabinoid system, increase the risk of developing obesity, and associated metabolic disorders in mice. The adipogenic effect of LA can be prevented by consuming sufﬁcient EPA and DHA to reduce arachidonic acid (AA, 20:4 Omega-6) pool and normalize endocannabinoid tone, the principle of the "Omega Balance Health Concept".
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